Retinol-binding protein 4 in obesity and metabolic dysfunctions

Retinol-binding protein 4 in human obesity.

Studies in mice suggest that adipocytes serve as glucose sensors and regulate systemic glucose metabolism through release of serum retinol-binding protein 4 (RBP4). This model has not been validated in humans. RBP4 was highly expressed in isolated mature human adipocytes and secreted by differentiating human adipocytes. In contrast to the animal data, RBP4 mRNA was downregulated in subcutaneous...

Retinol-Binding Protein 4 in Twins

OBJECTIVE Retinol-binding protein (RBP) 4 is an adipokine of which plasma levels are elevated in obesity and type 2 diabetes. The aims of the study were to identify determinants of plasma RBP4 and RBP4 mRNA expression in subcutaneous adipose tissue (SAT) and skeletal muscle and to investigate the association between RBP4 and in vivo measures of glucose metabolism. RESEARCH DESIGN AND METHODS ...

Retinol-binding protein 4 expression in visceral and subcutaneous fat in human obesity.

Retinol binding protein 4 (RBP4) is a novel adipokine which might be involved in the development of insulin resistance. The aim of the study was to investigate the expression of RBP4 mRNA in subcutaneous and visceral fat depots and the relationship between RBP4 plasma and mRNA levels relative to indices of adiposity and insulin resistance. In 59 Caucasian women (BMI 20 to 49 kg/m(2)) paired sam...

hev-capsid protein interacts with cytochrome p4502c8 and retinol-binding protein 4

association of retinol?binding protein 4 with metabolic syndrome in first?degree relatives of type 2 diabetic patients

background: retinol?binding protein 4 (rbp4) is known to regulate lipid and glucose metabolism and insulin resistance. the influences of rbp4 on metabolic syndrome (ms) are still unclear. the purpose of this study is to evaluate the association between serum levels of rbp4 and ms components in first?degree relations of type 2 diabetic patients. materials and methods: this cross?sectional study ...